Description

1-n-(3-Amino-2-Hydroxybutanoyl)-2',3'-Dideoxykanamycin A is a semi-synthetic derivative of the aminoglycoside antibiotic kanamycin, specifically modified to alter its pharmacological properties. This compound is of significant interest in pharmaceutical research and development for creating novel therapeutic agents with potentially improved efficacy or reduced side-effect profiles. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of advanced antibiotics and antimicrobial agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation aminoglycoside antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate structure-activity relationships (SAR) and mechanisms of bacterial resistance.
• Drug Discovery: A critical starting material for medicinal chemists developing new compounds to combat multi-drug resistant (MDR) bacterial infections.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Bioconjugation Studies: Utilized in research exploring the conjugation of antibiotic molecules to carriers or other functional groups for targeted delivery.

Basic Information

Product Name	1-n-(3-Amino-2-Hydroxybutanoyl)-2',3'-Dideoxykanamycin A
CAS No.	117325-82-3
Molecular Formula	C22H43N5O11
Molecular Weight	553.61 g/mol
Synonyms	2',3'-Dideoxykanamycin A 1-N-(3-Amino-2-hydroxybutanoyl) Derivative; 1-N-(3-Amino-2-hydroxybutanoyl)-2',3'-dideoxykanamycin A; 3-Amino-2-hydroxybutanoylkanamycin Derivative; Arbekacin Intermediate; Antibiotic 2230-C; (2S)-2-Amino-3-hydroxybutanoylkanamycin Derivative; 1-N-[(2S)-2-Amino-3-hydroxybutanoyl]-2',3'-dideoxykanamycin A
EINECS	Contact for details

Quality Control

Our production of 1-n-(3-Amino-2-Hydroxybutanoyl)-2',3'-Dideoxykanamycin A adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR spectroscopy, and tests for residual solvents and related substances. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure full traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.