Description

3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Trifluoromethyl-Arabinouridine is a high-purity, fluorinated nucleoside analog building block critical for advanced pharmaceutical research and development. This compound serves as a key synthetic intermediate in the production of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality raw materials for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of modified nucleoside analogs with potential antiviral and anticancer activity.
• Antiviral Drug Development: Used in research targeting the development of therapeutics against viruses such as hepatitis B (HBV) and hepatitis C (HCV).
• Oncology Research: Serves as a precursor for compounds being investigated for their antiproliferative effects in cancer cell lines.
• Biochemical Research: Employed in studies of enzyme mechanisms, particularly those involving DNA/RNA polymerases and nucleoside metabolism.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., C13, N15) compounds for metabolic and pharmacokinetic studies.

Basic Information

Product Name	3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Trifluoromethyl-Arabinouridine
CAS No.	117311-99-6
Molecular Formula	C25H18F4N2O7
Molecular Weight	534.42 g/mol
Synonyms	2'-Deoxy-2'-fluoro-5-trifluoromethylarabinouridine 3',5'-dibenzoate; 2'-Fluoro-2'-deoxy-5-trifluoromethyl-β-D-arabinofuranosyluracil 3',5'-dibenzoate; 5-Trifluoromethyl-2'-deoxy-2'-fluoroarabinouridine 3',5'-dibenzoate; 117311-99-6; 2'-F-5-CF3-AraU 3',5'-di-O-benzoate; 2'-Fluoro-5-trifluoromethyl-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-trifluoromethyluracil
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-5-Trifluoromethyl-Arabinouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.