Description

Israpafant CAS NO 117279-73-9 is a high-purity, synthetic chemical compound belonging to the class of platelet-activating factor (PAF) receptor antagonists. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of inflammatory and allergic response pathways. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in preclinical and clinical-stage drug discovery programs.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-inflammatory and anti-allergic therapeutics.
• Biochemical Assay Development: Used as a selective PAF receptor antagonist in in vitro and in vivo studies to elucidate biological mechanisms.
• Preclinical Studies: Serves as a critical material for pharmacological evaluation, toxicology assessments, and pharmacokinetic/pharmacodynamic (PK/PD) modeling.
• Contract Manufacturing: Supplied to CMOs for the cGMP-compliant synthesis of clinical trial materials (CTM) and non-commercial batches.
• Academic Research: Utilized in university and institutional labs for fundamental research into signal transduction and receptor biology.

Basic Information

Product Name	Israpafant
CAS No.	117279-73-9
Molecular Formula	C27H29N3O4
Molecular Weight	459.54 g/mol
Synonyms	WEB 2086; WEB-2086; 4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-oxopropyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-one; Israpafant (WEB 2086); 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-one, 4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-oxopropyl]-; Boehringer Ingelheim WEB 2086
EINECS	Contact for details

Quality Control

Our Israpafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.