Description

Brain Natriuretic Peptide-32 (BNP-32) is a specific 32-amino acid fragment of the prohormone pro-BNP, playing a critical role in cardiovascular homeostasis as a cardiac natriuretic hormone. This high-purity peptide is essential for research and diagnostic applications, serving as a key reference standard and active pharmaceutical ingredient. It is primarily utilized by pharmaceutical developers, clinical research organizations, and in vitro diagnostic (IVD) manufacturers focused on cardiovascular disease.

Application

• Reference Standard for Diagnostic Assays: Calibration and quality control material for clinical immunoassays measuring BNP levels in human plasma/serum, a critical biomarker for heart failure diagnosis and prognosis.
• Cardiovascular Research: Investigation of natriuretic peptide system physiology, receptor binding studies (NPR-A), and mechanisms of action in blood pressure regulation and fluid balance.
• Pharmaceutical Development: As a key intermediate or active substance in the development of novel cardiovascular therapeutics and peptide-based drugs.
• Bioanalytical Method Development: Used to develop and validate sensitive analytical methods such as HPLC, LC-MS/MS, and ELISA for peptide quantification.
• IVD Kit Manufacturing: A critical raw material incorporated into point-of-care testing (POCT) devices and laboratory test kits for cardiac markers.

Basic Information

Product Name	Brain Natriuretic Peptide-32
CAS No.	117217-27-3
Molecular Formula	C143H244N50O42S4
Molecular Weight	3464.0 g/mol
Synonyms	BNP-32; Brain Natriuretic Peptide (1-32), human; BNP (1-32); hBNP; Natriuretic Peptide B (1-32); Nesiritide (precursor); Porcine Brain Natriuretic Peptide-32; γ-Brain Natriuretic Peptide
EINECS	Contact for details

Quality Control

Our Brain Natriuretic Peptide-32 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity, meeting the stringent requirements for research and diagnostic use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications. We support development projects requiring alignment with GMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Determined by specific in vitro assay (e.g., cGMP induction)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.