Description

H-Dab(Fmoc)-Oh CAS NO 117106-22-6 is a protected amino acid derivative, specifically an Fmoc-protected form of 2,4-diaminobutyric acid (Dab), which is a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the unique Dab residue into peptide chains, enabling the creation of peptides with specific structural and functional properties for advanced research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Therapeutic Peptide Development: Used to incorporate the 2,4-diaminobutyric acid side chain, which can be functionalized for drug conjugation or to modulate peptide stability and activity.
• Bioconjugation and Linker Chemistry: The side-chain amine provides a reactive handle for attaching fluorescent dyes, biotin, or other payloads to peptides.
• Research into Antimicrobial Peptides (AMPs): Dab is a common component in many synthetic AMPs designed to combat drug-resistant bacteria.
• Chemical Biology Probes: Serves as a key intermediate in the synthesis of labeled peptides for studying protein-protein interactions and enzyme activity.
• GPCR Ligand and Neuropeptide Research: Used in the synthesis of peptide analogs targeting various receptors in neurological and metabolic research.

Basic Information

Product Name	H-Dab(Fmoc)-Oh
CAS No.	117106-22-6
Molecular Formula	C₂₀H₂₂N₂O₄
Molecular Weight	354.40 g/mol
Synonyms	Fmoc-Dab-OH; Nα-Fmoc-L-2,4-diaminobutyric acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-aminobutanoic acid; Fmoc-L-Dab-OH; N-Fmoc-L-2,4-diaminobutyric acid; Fmoc-2,4-diaminobutyric acid; Fmoc-DABA-OH; L-2,4-Diaminobutyric acid N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our H-Dab(Fmoc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.