Description

n-Fmoc-n-Methyl-o-tert-Butyl-L-Threonine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide superior steric protection and controlled reactivity during solid-phase and solution-phase peptide assembly. It is a critical building block for research and development in pharmaceutical discovery, enabling the synthesis of complex peptides and peptidomimetics with enhanced metabolic stability. This product is vital for medicinal chemists and process development scientists working on novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptide sequences, particularly where side-chain protection is required.
• Pharmaceutical R&D: Used as a crucial intermediate in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Enables the incorporation of non-natural, methylated amino acid structures to create peptides with improved bioavailability and receptor selectivity.
• Combinatorial Chemistry Libraries: Serves as a building block for generating diverse peptide libraries for high-throughput screening against biological targets.
• Process Development: Used in scaling up the production of therapeutic peptides under current Good Manufacturing Practice (cGMP) conditions.
• Bioconjugation: Facilitates the site-specific modification of peptides for drug delivery systems and diagnostic probes.

Basic Information

Product Name	n-Fmoc-n-Methyl-o-tert-Butyl-L-Threonine
CAS No.	117106-20-4
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	Fmoc-N-Me-Thr(tBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(1,1-dimethylethyl)-L-threonine; Fmoc-N-methyl-O-tert-butylthreonine; N-Fmoc-N-methyl-O-t-butyl-L-threonine; L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-, 1,1-dimethylethyl ester; Fmoc-N-Me-Thr(OtBu)-OH; N-Fmoc-N-methyl-O-tert-butylthreonine
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-Methyl-o-tert-Butyl-L-Threonine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical protocols, and specifications can be aligned with client-specific requirements for advanced research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.