Description

Fmoc-Thr(Tbu)-Opfp CAS NO 117088-31-0 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and controlled assembly of complex peptides, ensuring high coupling yields and minimizing side reactions. It is an essential building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality reagents for peptide production.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid active ester for the sequential construction of peptide chains on resin supports.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides, including hormones, antibiotics, and targeted drug candidates.
• Bioconjugation: Serves as a reagent for introducing threonine residues into proteins or other biomolecules under mild conditions.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and high-throughput screening of bioactive compounds.
• Peptide Library Construction: Enables the synthesis of diverse peptide arrays for epitope mapping and biomarker discovery.
• Academic & Industrial Research: A fundamental reagent in laboratories focused on synthetic chemistry, biochemistry, and medicinal chemistry.

Basic Information

Product Name	Fmoc-Thr(Tbu)-Opfp
CAS No.	117088-31-0
Molecular Formula	C25H24F5NO6
Molecular Weight	529.46 g/mol
Synonyms	Fmoc-Thr(O-t-Bu)-OPfp; Fmoc-O-tert-butyl-threonine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine pentafluorophenyl ester; Fmoc-L-threonine(O-t-butyl)-OPfp ester; Fmoc-Thr(tBu)-OPfp; Fmoc-Thr(OtBu)-OPfp; (2S,3R)-3-[(2-Methylpropan-2-yl)oxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid 2,3,4,5,6-pentafluorophenyl ester; N-α-Fmoc-O-tert-butylthreonine pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Tbu)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.