Description

Boc-Asp(Ofm)-Oh is a protected aspartic acid derivative, specifically the tert-butoxycarbonyl (Boc) and 9-fluorenylmethyl (Fm) ester form. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of aspartic acid while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptide chains.
• Pharmaceutical Intermediate: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Serves as a precursor for creating peptide conjugates for diagnostic or targeted drug delivery applications.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms.
• Custom Peptide Service Providers: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry and peptide science.

Basic Information

Product Name	Boc-Asp(Ofm)-Oh
CAS No.	117014-32-1
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-(9-fluorenylmethyl)-L-aspartic acid; Boc-L-Aspartic acid 9-fluorenylmethyl ester; Boc-Asp-OFm; Boc-Asp(OFm)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]butanedioic acid 4-(9H-fluoren-9-ylmethyl) ester; N-Boc-O-Fm-L-aspartic acid; Fmoc-Asp(OtBu)-OH (Note: This is a different, common protected form); L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(9H-fluoren-9-ylmethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Asp(Ofm)-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.