Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[3-[(Ethylamino)Methyl]-1-Pyrrolidinyl]-6,8-Difluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel fluoroquinolone antibiotics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents targeting resistant pathogens.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Critical precursor in the synthesis of advanced fluoroquinolone-class antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new antibacterial candidates.
• Process Chemistry & Scale-Up: Serves as a key starting material (KSM) or registered starting material (RSM) in cGMP manufacturing processes.
• Antibacterial Agent Synthesis: Specifically utilized for constructing molecules with enhanced potency against Gram-positive and Gram-negative bacteria.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: High-purity grades can be used as analytical reference standards for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[3-[(Ethylamino)Methyl]-1-Pyrrolidinyl]-6,8-Difluoro-1,4-Dihydro-4-Oxo-
CAS No.	116874-46-5
Molecular Formula	C20H23F2N3O3
Molecular Weight	391.41 g/mol
Synonyms	1-Cyclopropyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; PD 161148; PD-161148; ABT-492 intermediate; WCK 1754 intermediate; (1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-4-oxo-3-quinolinecarboxylic acid); 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6,8-difluoro-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-4-oxo-
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) that detail all critical quality attributes, ensuring compliance with the stringent requirements for pharmaceutical intermediates. Specifications can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.