Description

Fmoc-D-Ser-Oh CAS NO 116861-26-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound, featuring the fluorenylmethyloxycarbonyl (Fmoc) protecting group on the α-amino function, is critical for constructing peptides with precise stereochemistry and sequence control. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, stepwise assembly of custom peptide sequences using Fmoc-chemistry protocols.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, including hormones, antibiotics, and targeted therapeutics.
• Bioconjugation and Probe Development: Serves as a key intermediate for creating peptide-labeled probes, imaging agents, and antibody-drug conjugates (ADCs).
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Biochemical Research: Essential for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR) in a research setting.
• Production of Chiral Intermediates: Acts as a source of the D-serine moiety for the synthesis of more complex, non-natural chiral compounds.

Basic Information

Product Name	Fmoc-D-Ser-Oh
CAS No.	116861-26-8
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	Fmoc-D-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-serine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic acid; Fmoc-D-Ser-OH; D-Ser(Fmoc)-OH; N-Fmoc-D-serine; Fmoc-D-Ser; FMOC-D-SER-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Ser-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. Our products are characterized by HPLC, NMR, and optical rotation analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Optical Rotation [α]D20	+15.0° to +18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.