Description

2-(Trifluoromethoxy)Benzylsulphonyl Chloride is a high-purity organosulfur building block characterized by its reactive sulphonyl chloride group and trifluoromethoxy substituent. This compound is critical for introducing the 2-(trifluoromethoxy)benzylsulfonyl moiety into target molecules, a key step in the synthesis of advanced chemical entities. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of sulfonamide-based drug candidates, potentially targeting a range of therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the creation of specialized polymers or functional materials that require sulfonyl chloride linkages for cross-linking or modification.
• Chemical Biology Probes: Serves as a reagent for labeling or modifying biomolecules due to the reactivity of the sulphonyl chloride group with amines and alcohols.
• Custom Synthesis & Contract Manufacturing: An essential starting material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzylsulphonyl Chloride
CAS No.	116827-38-4
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.64 g/mol
Synonyms	2-(Trifluoromethoxy)benzylsulfonyl chloride; α-(Trifluoromethoxy)benzenemethanesulfonyl chloride; 1-[(Trifluoromethoxy)methyl]benzenesulfonyl chloride; (2-(Trifluoromethoxy)phenyl)methanesulfonyl chloride; 2-(Trifluoromethoxy)phenylmethanesulfonyl chloride; Benzene, 1-[(chlorosulfonyl)methyl]-2-(trifluoromethoxy)-; 2-(Trifluoromethoxy)benzyl sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethoxy)Benzylsulphonyl Chloride is produced and tested under a strict quality management system. We ensure high chemical purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.