Description

Fmoc-γ-Abu-Oh CAS NO 116821-47-7 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled elongation of peptide chains with its Fmoc-protected amino group and free carboxylic acid. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the Fmoc/t-Bu strategy, used to incorporate γ-aminobutyric acid (GABA) or its homologues into peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including neuromodulators, hormone analogs, and enzyme inhibitors.
• Bioconjugation & Probe Development: Used to create labeled peptides or peptide-drug conjugates for diagnostic and research applications.
• Material Science: Incorporation into peptide amphiphiles or self-assembling peptides for biomaterials and nanotechnology.
• Academic & Industrial R&D: A key reagent for exploring structure-activity relationships (SAR) in medicinal chemistry projects.

Basic Information

Product Name	Fmoc-γ-Abu-Oh
CAS No.	116821-47-7
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-γ-Abu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminobutanoic Acid; Fmoc-4-Aminobutanoic Acid; N-Fmoc-γ-aminobutyric acid; N-α-Fmoc-γ-aminobutyric acid; (9-Fluorenylmethyloxycarbonyl)-γ-aminobutyric acid; Fmoc-GABA-OH; Fmoc-Aminobutyric Acid
EINECS	Contact for details

Quality Control

Our Fmoc-γ-Abu-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.