Description

Fmoc-Thr(Galnac(Ac)3-α-D)-Oh is a sophisticated, orthogonally protected amino acid derivative essential for advanced solid-phase peptide synthesis (SPPS). This compound is specifically engineered for the complex synthesis of glycopeptides, particularly those containing O-linked glycosylation motifs. It is a critical building block for researchers and manufacturers in pharmaceutical development, enabling the creation of novel therapeutic peptides, vaccines, and diagnostic agents that mimic natural biological structures.

Application

• Glycopeptide & Glycoprotein Synthesis: A key intermediate for the chemical synthesis of O-linked glycopeptides, crucial for studying protein function and developing biotherapeutics.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including anticancer agents, antimicrobial peptides, and hormone analogs.
• Vaccine Development: Employed in constructing antigenic glycopeptide sequences for synthetic vaccine candidates against bacterial and viral infections.
• Diagnostic Reagent Production: Serves as a precursor for labeled glycopeptides used in immunoassays and diagnostic kits.
• Bioconjugation & Chemical Biology: Facilitates site-specific glycosylation of peptides and proteins for probe development and structure-activity relationship (SAR) studies.
• Academic & Institutional Research: A vital tool in biochemistry and molecular biology laboratories for investigating glycosylation pathways and carbohydrate-protein interactions.

Basic Information

Product Name	Fmoc-Thr(Galnac(Ac)3-α-D)-Oh
CAS No.	116783-35-8
Molecular Formula	C44H50N2O17
Molecular Weight	878.88 g/mol
Synonyms	Fmoc-Thr(Ac3-α-D-GalNAc)-OH; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine; Fmoc-L-Threonine[α-D-GalNAc(Ac)3]-OH; Fmoc-Thr[α-D-GalNAc(OAc)3]-OH; Fmoc-T(Ac3-α-D-GalNAc)-OH; Fmoc-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine; N-(9-Fluorenylmethoxycarbonyl)-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Galnac(Ac)3-α-D)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.