Description

5,7-Difluoro Isatin is a strategically fluorinated derivative of the versatile isatin heterocycle, serving as a critical building block in modern synthetic chemistry. Its value lies in the enhanced reactivity and unique electronic properties imparted by the fluorine atoms, enabling the development of novel compounds with targeted biological and material functions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for constructing complex molecules in drug discovery and specialty chemical synthesis. CAS No. 116570-41-3.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where fluorine atoms can improve metabolic stability and bioavailability.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, condensation reactions, and as a scaffold for constructing complex heterocyclic compounds.
• Material Science: Serves as a monomer or precursor for developing specialty polymers, dyes, and organic electronic materials with tailored properties.
• Biochemical Probe Development: Utilized in medicinal chemistry to create fluorinated probes and ligands for studying enzyme mechanisms and receptor binding.

Basic Information

Product Name	5,7-Difluoro Isatin
CAS No.	116570-41-3
Molecular Formula	C8H3F2NO2
Molecular Weight	183.11 g/mol
Synonyms	5,7-Difluoro-1H-indole-2,3-dione; 5,7-Difluoro-2,3-dihydroindole-2,3-dione; 1H-Indole-2,3-dione, 5,7-difluoro-; Isatin, 5,7-difluoro-; 5,7-Difluoroisatin; 2,3-Dioxo-5,7-difluoroindoline
EINECS	Contact for details

Quality Control

Our 5,7-Difluoro Isatin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to cGMP principles where applicable, ensuring the material meets the stringent requirements for research and development use in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.