Description

2-Trifluoromethylpyrimidine is a high-value fluorinated heterocyclic building block, essential for introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecular architectures. This compound matters for its critical role in modulating the physicochemical and biological properties of advanced materials and active pharmaceutical ingredients. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery, crop protection, and material science.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in cross-coupling and other transition metal-catalyzed reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers with tailored electronic and optical properties.
• Fluorine Chemistry Research: A fundamental building block for exploring new fluorination methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	2-Trifluoromethylpyrimidine
CAS No.	116470-67-8
Molecular Formula	C5H3F3N2
Molecular Weight	148.09 g/mol
Synonyms	Pyrimidine, 2-(trifluoromethyl)-; α,α,α-Trifluoro-2-picoline; 2-(Trifluoromethyl)pyrimidine; 2-Pyrimidinyl trifluoromethane; 2-CF3-Pyrimidine; 2-Trifluoromethyl-1,3-diazine
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylpyrimidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and are stored away from heat and ignition sources. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.