Description

α-Msh(4-11)Nh2, Ac-Nl4(4)-Orn(5)-Phe(7)-Glu(8)- CAS NO 116375-29-2 is a synthetic peptide fragment derived from the melanocyte-stimulating hormone (α-MSH) sequence, specifically engineered for enhanced stability and bioactivity. This compound is of significant interest for its role in modulating melanocortin receptors, which are key targets in metabolic and inflammatory research pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for metabolic disorders, skin pigmentation, and inflammation.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel melanocortin receptor (MCR) agonists and antagonists.
• Metabolic Disorder Studies: Investigation of its effects on appetite regulation, energy homeostasis, and glucose metabolism for potential anti-obesity and anti-diabetic drug candidates.
• Dermatology & Cosmeceuticals: Research into skin pigmentation processes and the development of treatments for vitiligo or compounds for tanning agents.
• Inflammation & Immunology Research: Exploration of anti-inflammatory pathways mediated through melanocortin receptors for conditions like rheumatoid arthritis or sepsis.
• Neuroscience: Study of neuroprotective effects and its role in neural circuits related to feeding behavior and stress response.
• Biochemical Assay Development: Used as a high-purity ligand in receptor binding assays, functional cell-based assays, and high-throughput screening (HTS) platforms.
• Peptide Chemistry & Conjugation: Serves as a building block for the synthesis of more complex peptide-drug conjugates or labeled probes for diagnostic imaging.

Basic Information

Item	Detail
Product Name	α-Msh(4-11)Nh2, Ac-Nl4(4)-Orn(5)-Phe(7)-Glu(8)- CAS NO 116375-29-2
CAS No.	116375-29-2
Molecular Formula	C58H84N16O15
Molecular Weight	1221.4 g/mol
Synonyms	Ac-[Nle4, D-Phe7]-α-MSH(4-11)-NH2; N-Acetyl-Nle4-Asp5-D-Phe7-Lys11-α-Melanocyte Stimulating Hormone Amide (4-11); Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2; Melanotan II Fragment (4-11); MT-II (4-11); α-MSH (4-11) analog; [Nle4, D-Phe7]-α-MSH(4-11) amide; SHU 9119 fragment
EINECS	Contact for details

Quality Control

Our α-Msh(4-11)Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. For cGMP-grade material or custom purity requirements, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Purity (HPLC) - Optional Higher Grade	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ± 10% of theoretical
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.