Description

α-Msh (4-11)Nh2, Ac-Nle(4)-Orn(5)-Glu(8)- CAS NO 116375-28-1 is a synthetic peptide fragment of the α-melanocyte-stimulating hormone (α-MSH), specifically the 4-11 sequence with an amidated C-terminus and an acetylated N-terminus. This compound is a potent and selective agonist for melanocortin receptors, particularly MC1R, making it a critical research tool for studying skin pigmentation, inflammation, and appetite regulation pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in metabolic, dermatological, and neurological research.

Application

• Biomedical Research: As a reference standard and agonist in studies of melanocortin receptor (MC1R, MC3R, MC4R) signaling, pharmacology, and function.
• Drug Discovery & Development: A key intermediate or lead compound for developing novel therapeutics targeting obesity, metabolic syndrome, and inflammatory skin conditions.
• Dermatology Studies: Investigation of melanogenesis, skin pigmentation disorders, and the role of α-MSH in UV-induced tanning and skin protection.
• Neuroscience Research: Exploring the role of melanocortin pathways in feeding behavior, energy homeostasis, and neuroinflammatory processes.
• In Vitro & In Vivo Assays: Used in cell-based assays and animal models to validate receptor activity and study physiological responses.
• Peptide Chemistry & Conjugation: Serves as a building block for synthesizing longer peptide sequences or for conjugation in bioconjugate chemistry.

Basic Information

Item	Details
Product Name	α-Msh (4-11)Nh2, Ac-Nle(4)-Orn(5)-Glu(8)- CAS NO 116375-28-1
CAS No.	116375-28-1
Molecular Formula	C46H74N14O12
Molecular Weight	1015.2 g/mol
Synonyms	Ac-[Nle4, Orn5, Glu8]-α-MSH (4-11)-NH2; α-MSH (4-11) amide, Ac-Nle-Orn-Glu-modified; Melanotan I fragment (4-11); Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2> (cyclic analog reference); Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 (full α-MSH reference); MC1R Agonist (4-11); [Ac-Nle4]-α-MSH (4-11)-NH2; Research Peptide 116375-28-1
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and content. Quality is assured through multiple orthogonal analytical techniques including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. We adhere to cGMP guidelines for research-grade materials, ensuring batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.