Description

Angiotensin II, Sar(1)-Aza-Val(3)-Ile(8)- is a potent, modified peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, designed for enhanced stability and receptor interaction. This compound is a critical research tool for studying the renin-angiotensin system (RAS), cardiovascular physiology, and hypertension. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular drug discovery and metabolic research.

Application

• Cardiovascular Research: Used as a reference standard and active agent in studies investigating blood pressure regulation, vascular smooth muscle contraction, and the pathophysiology of hypertension.
• Receptor Binding Assays: Serves as a high-affinity ligand for characterizing Angiotensin II type 1 (AT1) and type 2 (AT2) receptors in competitive binding studies.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and evaluate novel antagonists or modulators of the RAS pathway.
• Biochemical Studies: Facilitates research into signal transduction mechanisms, including G-protein coupling and second messenger systems activated by angiotensin receptors.
• In Vitro & Ex Vivo Models: Applied in organ bath experiments and cell-based assays to study vascular reactivity and endothelial function.
• Metabolic Disorder Research: Investigated for its role in conditions such as heart failure, renal disease, and insulin resistance.

Basic Information

Product Name	Angiotensin II, Sar(1)-Aza-Val(3)-Ile(8)-
CAS No.	116370-31-1
Molecular Formula	C45H68N14O10
Molecular Weight	965.1 g/mol
Synonyms	[Sar1,Aza-Val3,Ile8]-Angiotensin II; Saralasin Acetate (modified analog); [Sar1, Val5, Ala8] Angiotensin II (related variant); ATII antagonist analog; H-Sar-Arg-Val-Tyr-Val-His-Pro-Aza-Val-OH (sequence with Aza-Val); Angiotensin II receptor blocker research peptide; Sarcosine1, Aza-Valine3, Isoleucine8 Angiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Aza-Val(3)-Ile(8)- is produced under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, ensuring it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.