Description

4-Bromo-2-Fluoro-5-(Trifluoromethoxy)Aniline is a high-value, multi-functional aromatic amine building block characterized by its unique halogen and trifluoromethoxy substitution pattern. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling the development of advanced materials and active ingredients. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of specialized organic electronic materials, where its structure contributes to desired dielectric and luminescent properties.
• Polymer Chemistry: Acts as a monomer or modifier in the production of high-performance polymers, such as polyimides and polyamides, for electronics and aerospace applications.
• Chemical Research & Development: Employed as a versatile building block in organic synthesis for creating complex molecular architectures in academic and industrial R&D labs.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments, where its halogenated aniline structure provides color fastness and unique shades.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-(Trifluoromethoxy)Aniline
CAS No.	116367-67-0
Molecular Formula	C7H4BrF4NO
Molecular Weight	274.01 g/mol
Synonyms	5-Amino-2-bromo-1-fluoro-4-(trifluoromethoxy)benzene; 2-Fluoro-4-bromo-5-(trifluoromethoxy)aniline; 4-Bromo-2-fluoro-5-(trifluoromethoxy)benzenamine; 2-Fluoro-4-bromo-α,α,α-trifluoro-p-anisidine; 116367-67-0; 4-Bromo-2-fluoro-5-(trifluoromethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2-Fluoro-5-(Trifluoromethoxy)Aniline adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.