Description

Entacapone CAS NO 116314-67-1 is a potent and selective catechol-O-methyltransferase (COMT) inhibitor used as an active pharmaceutical ingredient (API). Its primary value lies in enhancing the efficacy and duration of action of levodopa/carbidopa therapy for patients with Parkinson's disease. This compound is essential for pharmaceutical manufacturers developing combination therapies aimed at managing motor fluctuations. High-purity Entacapone is critical for ensuring the safety, stability, and therapeutic consistency of the final drug product.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of anti-Parkinson's medications, often in fixed-dose combinations with levodopa and carbidopa.
• Neurological Disorder Research: Serves as a key reference standard and biochemical tool in preclinical studies targeting COMT enzyme activity.
• Generic Drug Manufacturing: A critical component for companies producing bioequivalent versions of branded Parkinson's disease treatments.
• Hospital & Compounding Pharmacy: Used in specialized compounding for tailored patient dosage regimens where standard commercial combinations are unsuitable.
• Analytical Standard: Employed in quality control laboratories for HPLC, LC-MS, or spectroscopic assay development and validation.
• Clinical Trial Material (CTM): Supplied for use in Phase I-IV clinical studies investigating new neurological therapies or combination formulations.

Basic Information

Product Name	Entacapone
CAS No.	116314-67-1
Molecular Formula	C14H15N3O5
Molecular Weight	305.29 g/mol
Synonyms	(E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; OR-611; Comtan (brand name); COMT Inhibitor; Entacapon; E-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
EINECS	Contact for details

Quality Control

Our Entacapone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, confirming compliance with in-house specifications aligned with major pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.