Description

Leiurotoxin I CAS NO 116235-63-3 is a potent, highly specific peptide neurotoxin originally isolated from scorpion venom. This compound is of significant value in neuroscience and pharmacological research due to its selective interaction with potassium channels. It is primarily utilized by research institutions and pharmaceutical companies engaged in ion channel studies, neurobiology, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a specific tool for studying the structure, function, and modulation of potassium (K+) channels in neuronal and other excitable tissues.
• Pharmacological Studies: Used in high-throughput screening (HTS) assays and binding studies to identify and characterize new channel modulators or drug candidates.
• Toxicology & Venom Research: Serves as a reference standard for the analysis of scorpion venom components and for studying the mechanisms of animal toxins.
• Biochemical Reagent: Employed in the purification and isolation of specific receptor proteins via affinity chromatography techniques.
• Drug Discovery Pipeline: Integral in target validation and mechanistic studies for conditions related to channelopathies, such as certain neurological and cardiac disorders.

Basic Information

Product Name	Leiurotoxin I
CAS No.	116235-63-3
Molecular Formula	C185H284N52O53S7
Molecular Weight	~4235.9 g/mol
Synonyms	Leiurotoxin I; Iberiotoxin; Kaliotoxin; Charybdotoxin inhibitor; Potassium channel toxin α-KTx 1.2; ShK toxin analogue; Scorpion toxin peptide; Leiurotoxin 1
EINECS	Contact for details

Quality Control

Our Leiurotoxin I is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioactivity. We adhere to relevant standards for research-grade biochemicals, ensuring the material's suitability for advanced neuroscientific and pharmacological studies.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquotting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity	Confirmed by functional assay (e.g., channel inhibition)
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.