Description

7'-(3-Hydroxypropyl)Fortimicin A is a semi-synthetic derivative of the aminoglycoside antibiotic Fortimicin A. This compound is significant for its role as a key intermediate in the research and development of novel antimicrobial agents, particularly in the study of structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation antibiotics to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced aminoglycoside antibiotic candidates.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate mechanisms of action and resistance.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the fortimicin core to enhance potency, reduce toxicity, or alter the spectrum of activity.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for related pharmaceutical compounds.
• Bioconjugation Studies: The hydroxypropyl side chain provides a handle for further chemical modification and conjugation with other molecules.

Basic Information

Product Name	7'-(3-Hydroxypropyl)Fortimicin A
CAS No.	116184-08-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fortimicin A, 7'-(3-Hydroxypropyl)-; 3-Hydroxypropylfortimicin A; Antibiotic FR-31564 derivative; (2R,3S,4R,5S,6R)-5-Amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,4R,5S)-3,5-diamino-2-[(2S,3R)-3-[(2R,3S,4R,5S)-5-[(1R)-1,2-Dihydroxyethyl]-3,4-dihydroxyoxolan-2-yl]oxy-2-hydroxybutyl]oxy-4-hydroxyoxolan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4-diol; 3'-Deoxy-3'-(3-hydroxypropyl)fortimicin A
EINECS	Contact for details

Quality Control

Our 7'-(3-Hydroxypropyl)Fortimicin A is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.