Description

1-tert-Butyl-6-Fluoro-7-(3-Methyl-Piperazin-1-Yl)-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural features for potent antimicrobial activity. It is essential for pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers targeting the synthesis of next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A critical building block in the multi-step synthesis of advanced fluoroquinolone antibiotic candidates.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Fine Chemical Intermediate: Utilized in the production of specialized chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-tert-Butyl-6-Fluoro-7-(3-Methyl-Piperazin-1-Yl)-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid
CAS No.	116163-02-1
Molecular Formula	C19H24FN3O3
Molecular Weight	361.41 g/mol
Synonyms	1-(1,1-Dimethylethyl)-6-fluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 7-(3-Methylpiperazin-1-yl)-1-tert-butyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-tert-Butyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; ABT-719 Intermediate; Fluoroquinolone Intermediate; 116163-02-1
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl-6-Fluoro-7-(3-Methyl-Piperazin-1-Yl)-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.