Description

L-Alanine-(3-3H) is a high-specific-activity, tritium-labeled isotopologue of the essential amino acid L-alanine. This radiochemical is critical for advanced metabolic and biochemical tracer studies, enabling precise tracking and quantification in complex biological systems. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) research, proteomics, and the study of amino acid transport mechanisms.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the metabolic pathways, absorption, distribution, and excretion of new pharmaceutical compounds.
• Biochemical Pathway Analysis: Enables detailed mapping of alanine metabolism, gluconeogenesis, and the alanine cycle in cellular and animal models.
• Protein Synthesis and Turnover Research: Incorporated into peptides and proteins to study synthesis rates, degradation, and protein dynamics in vivo and in vitro.
• Amino Acid Transport Studies: Serves as a tool to characterize and quantify the function of specific amino acid transporters across cell membranes.
• Medical Imaging Research: Acts as a precursor for the development of positron emission tomography (PET) tracers, although further synthesis is required.
• Quality Control in Radiopharmaceuticals: Used as a reference standard in the production and validation of other labeled compounds.

Basic Information

Product Name	L-Alanine-(3-3H)
CAS No.	116003-63-5
Molecular Formula	C₃H₄TNO₂
Molecular Weight	~91.1 g/mol (exact mass depends on specific activity)
Synonyms	(S)-2-Amino(3-3H)propanoic acid; L-2-Aminopropionic-3-3H acid; Tritiated L-alanine; L-Alanine-3-t; [3-3H]-L-Alanine; H-Ala-OH(3-3H); (S)-Alanine-(3-3H); Alanine, L-, labeled with tritium
EINECS	Contact for details

Quality Control

Every batch of L-Alanine-(3-3H) is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including radiochemical purity (typically >97% by HPLC), specific activity (Ci/mmol), and chemical purity. Our production adheres to cGMP guidelines for research radiochemicals, ensuring traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or as specified on the label. The product should be stored in an area designated for radioactive materials, in accordance with local radiation safety regulations. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, Co-injection)	Conforms
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	10 - 100 Ci/mmol (Custom ranges available)
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol/Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.