Description

H-L-β-Glu(Otbu)-Oh is a protected amino acid derivative, specifically a tert-butyl ester of a glutamic acid analog, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides and peptidomimetics with precise stereochemistry. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical suppliers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid or its analogs into peptide chains.
• Pharmaceutical Research: Building block for the development of novel peptide-based drugs targeting metabolic disorders, oncology, and neurological conditions.
• Bioconjugation: Used to introduce functional handles or linkers onto peptides for antibody-drug conjugates (ADCs) or diagnostic imaging probes.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Employed in biochemical studies to investigate enzyme-substrate interactions and protein structure-function relationships.
• Process Development: Serves as a starting material for scaling up the production of specific peptide sequences under GMP conditions.

Basic Information

Product Name	H-L-β-Glu(Otbu)-Oh
CAS No.	115939-63-4
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	H-β-Glu(OtBu)-OH; (S)-2-Amino-4-(tert-butoxy)-4-oxobutanoic acid; L-β-Homoglutamic acid 1-tert-butyl ester; β-Glutamic acid, 1-(1,1-dimethylethyl) ester, L-; Fmoc-β-Glu(OtBu)-OH precursor; Boc-β-Glu(OtBu)-OH precursor; Protected β-homoglutamic acid; tert-Butyl L-β-homoglutamate
EINECS	Contact for details

Quality Control

Our H-L-β-Glu(Otbu)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.