Description

Suc-Gly-Pro-Pna CAS NO 115846-45-2 is a specialized synthetic peptide substrate designed for biochemical research and diagnostic applications. This compound is critical for studying and quantifying the activity of specific proteolytic enzymes, such as dipeptidyl peptidase IV (DPP-IV) and related peptidases. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics industries who require high-purity, reliable substrates for enzyme kinetics, inhibitor screening, and assay development.

Application

• Enzyme Activity Assays: Primary substrate for the colorimetric or fluorometric detection and quantification of DPP-IV (CD26) enzyme activity.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel DPP-IV inhibitors for therapeutic development (e.g., for type 2 diabetes).
• Biochemical Research: A key reagent in fundamental research on peptidase function, signal transduction, and immune regulation.
• Diagnostic Kit Manufacturing: Incorporated into in-vitro diagnostic (IVD) kits for clinical measurement of DPP-IV levels in serum or plasma samples.
• Quality Control Testing: Employed in pharmaceutical QC labs to test the potency and consistency of enzyme-based biopharmaceuticals.
• Academic & Institutional Labs: Standard reagent for teaching and advanced research in biochemistry, molecular biology, and enzymology courses.

Basic Information

Product Name	Suc-Gly-Pro-Pna
CAS No.	115846-45-2
Molecular Formula	C19H24N4O7
Molecular Weight	420.42 g/mol
Synonyms	Succinyl-Glycyl-Prolyl-4-Nitroanilide; Suc-Gly-Pro-pNA; Suc-Gly-Pro-4-NA; N-Succinyl-Gly-Pro-p-nitroanilide; DPP-IV Substrate; Dipeptidyl Peptidase IV Substrate; Gly-Pro-pNA derivative; EC 3.4.14.5 Substrate
EINECS	Contact for details

Quality Control

Every batch of Suc-Gly-Pro-Pna is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as HPLC purity, water content, and functional activity in standard enzyme assays. Our quality system is designed to meet the exacting requirements of research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Functional Activity	≥ 95% of reference standard
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.