Description

2-Bromoporphobilinogen is a key brominated derivative of porphobilinogen, a fundamental pyrrole building block in the biosynthesis of heme and chlorophyll. This specialized intermediate is critical for research and development in the fields of porphyrin chemistry and photodynamic therapy. It is primarily utilized by pharmaceutical researchers, organic chemists, and advanced material scientists working on novel photosensitizers, catalysts, and diagnostic agents.

Application

• Pharmaceutical Research & Development: As a crucial precursor for synthesizing novel brominated porphyrins and chlorins with potential applications in photodynamic therapy (PDT) for cancer treatment.
• Organic Synthesis & Chemical Intermediates: Serves as a versatile building block for the synthesis of complex tetrapyrrole macrocycles, including corroles and expanded porphyrins, for catalytic and sensing applications.
• Biochemical Studies: Used in enzymatic studies to investigate the biosynthetic pathway of heme and vitamin B12, particularly the role of porphobilinogen deaminase.
• Material Science: Employed in the development of advanced organic electronic materials, light-harvesting arrays, and molecular wires due to its conjugated pyrrole structure.
• Diagnostic Agent Development: A potential starting material for creating targeted imaging agents or photosensitizers for fluorescence-guided surgery or photodiagnosis.

Basic Information

Product Name	2-Bromoporphobilinogen
CAS No.	115828-91-6
Molecular Formula	C10H11BrN2O4
Molecular Weight	303.11 g/mol
Synonyms	2-Bromo-5-[(3-carboxy-4-(aminomethyl)-1H-pyrrol-2-yl)methyl]-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid; 2-Bromo-PBG; 2-BrPBG; 2-Bromomonopyrrole; 5-(2-Bromo-3,4-dicarboxy-5-(aminomethyl)pyrrol-1-yl)pentanoic acid; Bromoporphobilinogen
EINECS	Contact for details

Quality Control

Our 2-Bromoporphobilinogen is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles for laboratory chemicals to support our clients' regulatory and research integrity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Off-white to light brown powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.