Description

2-(2-Amino-5-Nitro-6-Oxo-1,6-Dihydropyrimidin-4-Yl)-3-(3-Thienyl)Propiononitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure, designed for the synthesis of novel active pharmaceutical ingredients (APIs). Its molecular architecture, featuring fused pyrimidine and thiophene rings, makes it a critical building block for research and development in targeted drug discovery. This compound is essential for pharmaceutical R&D teams and fine chemical manufacturers focused on creating new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting specific enzymes or receptors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in the production of complex APIs for potential use in various therapeutic areas.
• Biochemical Research: Employed as a specialized reagent in biochemical assays and as a probe for studying biological pathways.
• Fine Chemical Production: Utilized in the custom synthesis of high-value, complex organic molecules for specialized industrial applications.

Basic Information

Product Name	2-(2-Amino-5-Nitro-6-Oxo-1,6-Dihydropyrimidin-4-Yl)-3-(3-Thienyl)Propiononitrile
CAS No.	115787-67-2
Molecular Formula	C11H9N5O3S
Molecular Weight	291.28 g/mol
Synonyms	2-(2-Amino-5-nitro-6-oxo-1,6-dihydropyrimidin-4-yl)-3-(thiophen-3-yl)propanenitrile; 3-(3-Thienyl)-2-(2-amino-5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)propiononitrile; 2-(2-Amino-5-nitro-6-oxo-1,4,5,6-tetrahydropyrimidin-4-yl)-3-(3-thienyl)propiononitrile; 4-(2-Cyano-2-(thiophen-3-yl)ethyl)-5-nitro-2-amino-6-pyrimidinone; 115787-67-2; Advanced Pyrimidine-Thiophene Intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Amino-5-Nitro-6-Oxo-1,6-Dihydropyrimidin-4-Yl)-3-(3-Thienyl)Propiononitrile undergoes rigorous analytical testing to ensure it meets the stringent purity and consistency standards required for pharmaceutical R&D. Our quality assurance protocols are designed to support cGMP compliance for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.