Description

(D-Arg1,D-Phe5,D-Trp7,11)-Substance P is a potent and selective synthetic peptide antagonist of the neurokinin-1 (NK1) receptor, derived from the native Substance P sequence with key D-amino acid substitutions. This engineered modification significantly enhances its metabolic stability and receptor binding affinity, making it a critical research tool for studying neurogenic inflammation, pain pathways, and central nervous system disorders. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pharmacology, and drug discovery programs.

Application

• Neuroscience Research: A standard tool for investigating the role of Substance P and NK1 receptors in pain transmission, neurogenic inflammation, and emesis.
• Pharmacological Studies: Used in in vitro and in vivo assays to characterize NK1 receptor function, screen potential antagonists, and validate drug targets.
• Drug Discovery & Development: Serves as a reference compound and positive control in high-throughput screening (HTS) campaigns for novel analgesic or anti-inflammatory therapeutics.
• Cell Signaling Pathways: Employed to study intracellular signaling cascades (e.g., involving phospholipase C and calcium mobilization) activated by the NK1 receptor.
• Animal Model Studies: Used to establish preclinical models of pain, migraine, asthma, and inflammatory bowel disease to evaluate therapeutic efficacy.

Basic Information

Product Name	(D-Arg1,D-Phe5,D-Trp7,11)-Substance P
CAS No.	115760-58-2
Molecular Formula	C78H104N22O13S
Molecular Weight	1622.9 g/mol
Synonyms	[D-Arg1, D-Phe5, D-Trp7,9, Leu11]Substance P; (D-Arg1,D-Phe5,D-Trp7,9,Leu11)-Substance P; SP Antagonist; Neurokinin-1 Receptor Antagonist; NK1R Antagonist; Substance P (1-11) Antagonist; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P
EINECS	Contact for details

Quality Control

Our peptide products are synthesized under cGMP-like conditions and undergo rigorous analytical characterization to ensure identity, purity, and biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from HPLC, MS, and amino acid analysis. We adhere to stringent quality standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.