Description

Phe-Ala-Ala-p-Nitro-Phe-Phe-Val-Leu 4-Pyridylmethyl Ester is a synthetic peptide derivative, specifically an octapeptide ester, designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block or a specialized substrate in the study of enzyme kinetics, protease specificity, and peptide-based drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and biotechnology companies focused on developing novel therapeutic agents and diagnostic tools.

Application

• Protease/Enzyme Substrate: Used as a specific chromogenic or fluorogenic substrate for studying the activity and inhibition of proteolytic enzymes like chymotrypsin, subtilisin, or other serine/cysteine proteases.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate in the research and development of peptide-based pharmaceuticals and bioactive compounds.
• Biochemical Research: Employed in mechanistic studies to understand peptide bond cleavage, enzyme specificity, and the structure-activity relationships (SAR) of peptide sequences.
• Diagnostic Development: Acts as a component in the design of assays and diagnostic kits for detecting specific enzyme activities relevant to disease states.
• Inhibitor Screening: Utilized in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for therapeutic applications.

Basic Information

Item	Detail
Product Name	Phe-Ala-Ala-p-Nitro-Phe-Phe-Val-Leu 4-Pyridylmethyl Ester
CAS No.	115389-04-3
Molecular Formula	C58H72N10O12
Molecular Weight	1101.26 g/mol
Synonyms	F-A-A-pNO2-F-F-V-L-OPic; FAAPNFFVL-OPic; Phenylalanyl-alanyl-alanyl-p-nitro-phenylalanyl-phenylalanyl-valyl-leucine 4-pyridylmethyl ester; Octapeptide Substrate; Protease Substrate III; Suc-AAPF-pNA (structural analog); Chymotrypsin Substrate; p-Nitro-Phe containing peptide ester
EINECS	Contact for details

Quality Control

Every batch of Phe-Ala-Ala-p-Nitro-Phe-Phe-Val-Leu 4-Pyridylmethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97% (on dried basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.