Description

Siguazodan CAS NO 115344-47-3 is a selective phosphodiesterase III (PDE III) inhibitor belonging to the imidazoquinazolinone class. This compound is of significant interest in pharmaceutical research and development due to its potent cardiotonic and vasodilatory properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic agents targeting cardiovascular diseases.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of cardiotonic drugs.
• Biochemical Studies: Used as a selective tool compound in vitro and in vivo to study the physiological role and inhibition mechanisms of PDE III enzymes.
• Preclinical Development: Serves as a lead compound or a structural analog for optimizing pharmacokinetic and pharmacodynamic properties in new drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the synthesis of clinical trial materials under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for cardiovascular pharmacology and signal transduction pathway research.

Basic Information

Product Name	Siguazodan
CAS No.	115344-47-3
Molecular Formula	C19H19N5O2
Molecular Weight	349.39 g/mol
Synonyms	1-Cyclopropyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-h]isoquinolin-2(3H)-one; SK&F 94836; SKF-94836; 1-Cyclopropyl-1,6,7,8,9,9a-hexahydroimidazo[4,5-h]isoquinolin-2(3H)-one; PDE III Inhibitor Siguazodan
EINECS	Contact for details

Quality Control

Our Siguazodan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.