Description

Guanidinophenylalanine-2-Naphthylamide CAS NO 115336-09-9 is a specialized biochemical reagent featuring a guanidino group and a naphthylamide fluorophore. This compound is valued for its role as a synthetic intermediate and a potential substrate or inhibitor in enzymatic studies, particularly for proteases like trypsin and thrombin. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, biochemical assay development, and proteomics research.

Application

• Protease Research: Acts as a fluorogenic or chromogenic substrate for the study of serine proteases, including trypsin, thrombin, and related enzymes.
• Biochemical Assay Development: Used in high-throughput screening (HTS) platforms to identify and characterize enzyme inhibitors for therapeutic targets.
• Pharmaceutical Intermediates: Serves as a key synthetic building block in the preparation of more complex molecules for drug discovery programs.
• Diagnostic Reagents: Can be incorporated into diagnostic kits for measuring protease activity in clinical or research samples.
• Academic Research: Employed in university and institutional labs for fundamental studies on enzyme kinetics and mechanism of action.

Basic Information

Product Name	Guanidinophenylalanine-2-Naphthylamide
CAS No.	115336-09-9
Molecular Formula	C20H21N5O2
Molecular Weight	363.42 g/mol
Synonyms	Nα-(2-Naphthyl)-Nω-(Nα-benzyloxycarbonyl-L-arginyl)-L-phenylalaninamide; Z-Arg-Phe-2-Nap; Benzyloxycarbonyl-arginyl-phenylalanine 2-naphthylamide; L-Phenylalanine, N-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-, 1-(2-naphthalenyl) ester; Protease Substrate; Fluorogenic Arginine Derivative; Trypsin Substrate Analog
EINECS	Contact for details

Quality Control

Our Guanidinophenylalanine-2-Naphthylamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.