Description

Vancomycin Hexapeptide is a synthetic peptide derivative of the glycopeptide antibiotic vancomycin. This compound is of significant interest in pharmaceutical research and development, particularly for studying antibiotic mechanisms and resistance. It serves as a crucial intermediate and reference standard for scientists in the pharmaceutical and biotechnology sectors focused on novel antimicrobial agents and diagnostic applications.

Application

• Pharmaceutical Research Intermediate: A key building block in the synthesis and study of novel vancomycin-derived antibiotics.
• Mechanistic Studies: Used to investigate the binding interactions and mode of action of glycopeptide antibiotics against bacterial cell walls.
• Antibiotic Resistance Research: Employed as a tool compound to understand and combat vancomycin-resistant bacterial strains (e.g., VRE, VRSA).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC and LC-MS assays.
• Bioconjugation & Probe Development: Utilized in creating fluorescent or affinity-tagged probes for cellular imaging and target identification.
• Biochemical Assays: Acts as a ligand or inhibitor in enzymatic and binding assays to screen for new therapeutic compounds.

Basic Information

Product Name	Vancomycin Hexapeptide
CAS No.	115236-65-2
Molecular Formula	C58H75Cl2N9O24
Molecular Weight	Approx. 1329.1 g/mol
Synonyms	Vancomycin Aglycone Hexapeptide; N-[(3S,6R,9S,12R,15S,18R,21S,24R,27S,30S,33S)-30-[(2S,5S,6S)-5-Amino-2-carbamoyl-4,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]-6,9,18,21,24,27,33-heptakis(2-amino-2-oxoethyl)-12-(carboxymethyl)-3-[(1R)-1-hydroxyethyl]-15-[(4-hydroxybenzoyl)amino]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazatetratriacontan-34-yl]-3,5-dichloro-2-hydroxybenzamide; Vancomycin Peptide Core; D-Ala-D-Ala binding peptide
EINECS	Contact for details

Quality Control

Our Vancomycin Hexapeptide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.