Description

(Arg6,D-Trp7,9,n-Me-Phe8)-Substance P (6-11) is a synthetic, biologically active peptide analog of the neuropeptide Substance P. This compound is specifically engineered for enhanced receptor selectivity and metabolic stability, making it a critical research tool in neuropharmacology. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on neuroscience, pain management, and inflammatory pathways.

Application

• Neuroscience Research: As a potent and selective tachykinin NK1 receptor antagonist for studying neurogenic inflammation, pain transmission, and central nervous system disorders.
• Pharmacological Studies: Used in vitro and in vivo to investigate the role of Substance P in emesis, depression, anxiety, and migraine pathways.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutics targeting neurokinin receptors.
• Biochemical Assays: Employed in receptor binding assays, functional cell-based tests, and signal transduction research to characterize antagonist activity.
• Academic & Institutional Research: A key reagent for universities and research institutes exploring peptidergic systems and their modulation.

Basic Information

Product Name	(Arg6,D-Trp7,9,n-Me-Phe8)-Substance P (6-11)
CAS No.	115150-59-9
Molecular Formula	C58H81N17O8
Molecular Weight	1112.4 g/mol
Synonyms	[Arg6, D-Trp7,9, N-Me-Phe8]-Substance P (6-11); Substance P (6-11) analog; SP (6-11) antagonist; Tachykinin NK1 receptor antagonist; (Arg6,D-Trp7,9,N-Me-Phe8)-SP(6-11); Neurokinin-1 receptor antagonist; Sendide analog; GR 71251 analog
EINECS	Contact for details

Quality Control

Every batch of (Arg6,D-Trp7,9,n-Me-Phe8)-Substance P (6-11) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support research reproducibility, including HPLC purity, mass spectrometry (MS) confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, identity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.