Description

N,o-Bis(Fluorenylmethyloxycarbonyl)Tyrosine Hydroxysuccinimide Ester is a specialized, high-purity amino acid derivative designed for advanced peptide synthesis and bioconjugation. This compound matters because it serves as a critical building block for the controlled introduction of protected tyrosine residues, enabling the development of complex peptides and protein-based therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in solid-phase peptide synthesis (SPPS), proteomics research, and the development of novel biopharmaceuticals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected tyrosine derivative, it is a key reagent for the sequential assembly of peptides, particularly where tyrosine incorporation is required.
• Bioconjugation and Labeling: The active NHS ester moiety facilitates efficient coupling to primary amines on proteins, antibodies, or other biomolecules for creating labeled probes or antibody-drug conjugates (ADCs).
• Proteomics and Biochemical Research: Used in the synthesis of custom peptides for enzyme substrates, inhibitors, or antigens in various research applications.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development stages of peptide-based drugs and therapeutic agents.
• Material Science: Potential use in the synthesis of peptide-polymer hybrids or biomimetic materials where specific amino acid sequences are necessary.

Basic Information

Product Name	N,o-Bis(Fluorenylmethyloxycarbonyl)Tyrosine Hydroxysuccinimide Ester
CAS No.	115136-02-2
Molecular Formula	C41H34N2O9
Molecular Weight	698.72 g/mol
Synonyms	Fmoc-Tyr(2,6-diFmoc)-OH N-hydroxysuccinimide ester; N-{N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-tyrosyl}oxy-2,5-pyrrolidinedione; Bis-Fmoc-Tyrosine NHS Ester; Nα,O-Bis(9-fluorenylmethoxycarbonyl)tyrosine N-hydroxysuccinimide ester; Fmoc-Tyr(Fmoc)-OSu; Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our N,o-Bis(Fluorenylmethyloxycarbonyl)Tyrosine Hydroxysuccinimide Ester is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive research and development applications. Each batch is analyzed to confirm identity, purity, and suitability for peptide synthesis. Certificates of Analysis (COA) detailing specific chromatographic and spectroscopic data are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.