Description

Cholecystokinin (26-33), Tyr-Gly-(Nle(28,31),4-No2-Phe(33)) is a synthetic, biologically active peptide fragment of the cholecystokinin hormone, specifically the C-terminal octapeptide sequence with key modifications. This compound is a critical research tool for studying gastrointestinal and central nervous system functions, particularly as a potent and selective CCK-B receptor agonist. It is essential for pharmaceutical R&D, academic research, and diagnostic development in neurobiology and gastroenterology.

Application

• Neuroscience Research: Used as a selective agonist to study the role of CCK-B receptors in anxiety, panic disorders, pain perception, and memory.
• Gastrointestinal Physiology Studies: Investigates the regulation of pancreatic enzyme secretion, gallbladder contraction, and gut motility.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening programs for novel CNS and GI therapeutics.
• Biochemical Assay Development: Employed in the development and validation of receptor binding assays (RBA) and functional cellular assays.
• Academic & Clinical Research: Supports fundamental research into hormone-receptor interactions and signal transduction pathways.
• Diagnostic Reagent Component: Potential use in specialized diagnostic kits for research purposes.

Basic Information

Product Name	Cholecystokinin (26-33), Tyr-Gly-(Nle(28,31),4-No2-Phe(33))
CAS No.	115136-01-1
Molecular Formula	C52H68N12O14S
Molecular Weight	1093.23 g/mol
Synonyms	CCK-8 (sulfated), unsulfated; CCK (26-33), non-sulfated; Cholecystokinin Octapeptide, non-sulfated; Sincalide analog; CCK-B Receptor Agonist; Tyr-Gly-Nle-Asp-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 (modified); A-71623; [Nle28,31,4-NO2-Phe33]CCK(26-33)
EINECS	Contact for details

Quality Control

Our Cholecystokinin (26-33), Tyr-Gly-(Nle(28,31),4-No2-Phe(33)) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, mass spectrometry (MS) for molecular weight verification, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical molecular weight
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.