Description

4-(Trifluoromethyl)-L-Phenylalanine is a high-value, non-natural amino acid derivative featuring a trifluoromethyl group on the phenyl ring. This compound is essential for its role as a key chiral building block in pharmaceutical research and development, offering unique metabolic stability and lipophilicity to peptide-based drug candidates. It is primarily sought after by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated aromatic side chains, enhancing peptide stability and bioavailability.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators that leverage the properties of fluorine.
• Bioconjugation & Probe Development: Utilized in creating labeled peptides and bioconjugates for diagnostic assays and biochemical research.
• Material Science: A precursor for specialty polymers and advanced materials where fluorinated aromatic groups impart specific chemical resistance or surface properties.
• Academic & Contract Research: Employed in medicinal chemistry programs and as a reference standard in analytical laboratories.

Basic Information

Product Name	4-(Trifluoromethyl)-L-Phenylalanine
CAS No.	114926-38-4
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	L-4-(Trifluoromethyl)phenylalanine; (S)-2-Amino-3-[4-(trifluoromethyl)phenyl]propanoic acid; 4-CF3-L-Phe; F3C-Phe-OH; p-Trifluoromethyl-L-phenylalanine; (S)-3-(4-Trifluoromethylphenyl)alanine; 4-(Trifluoromethyl)-L-Phe; 4-TFM-L-Phenylalanine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.