Description

(R)-n-Acetyl-5-Fluoro-Trp-Ome CAS NO 114872-80-9 is a high-purity, chiral fluorinated tryptophan derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined, fluorinated indole scaffold essential for modulating the biological activity and metabolic stability of drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potent, fluorinated drug candidates targeting specific biological pathways.
• Protease Inhibitor Research: Used in the development of selective enzyme inhibitors where the fluorinated tryptophan moiety is crucial for binding affinity.
• Peptidomimetics & Constrained Peptides: Incorporated into peptide analogs to enhance stability, bioavailability, and receptor selectivity.
• Fluorine-Containing Bioactive Molecule Libraries: Serves as a valuable scaffold for medicinal chemistry and high-throughput screening to discover new lead compounds.
• Metabolic Stability Studies: The fluorine atom is used to block metabolic hot spots, making this derivative vital for studying and improving the pharmacokinetic profiles of potential drugs.
• Asymmetric Synthesis Catalyst/ Ligand Development: Can be utilized in the design of novel chiral catalysts or ligands for enantioselective transformations.

Basic Information

Product Name	(R)-n-Acetyl-5-Fluoro-Trp-Ome
CAS No.	114872-80-9
Molecular Formula	C₁₄H₁₅FN₂O₃
Molecular Weight	278.28 g/mol
Synonyms	(R)-Methyl 2-acetamido-3-(5-fluoro-1H-indol-3-yl)propanoate; (R)-N-Acetyl-5-fluorotryptophan methyl ester; (R)-5-Fluoro-N-acetyltryptophan methyl ester; Methyl (R)-2-acetamido-3-(5-fluoro-1H-indol-3-yl)propanoate; (R)-Ac-5-F-Trp-OMe; (R)-Ac-5-F-Trp-Me; (R)-5-Fluoro-1H-indole-3-propanoic acid, α-(acetylamino)-, methyl ester, (αR)-; (R)-α-Acetamido-5-fluorotryptophan methyl ester
EINECS	Contact for details

Quality Control

Our (R)-n-Acetyl-5-Fluoro-Trp-Ome is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.