Description

Fondaparinux Sodium is a synthetic, selective, and potent inhibitor of activated Factor X (FXa), representing a key class of antithrombotic agents. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of anticoagulant therapies. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of injectable anticoagulant drugs.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of injectable anticoagulant medications for the prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Biosimilar Development: Critical reference standard and starting material for companies developing biosimilar versions of branded fondaparinux products.
• Clinical Research: Used in preclinical and clinical studies to investigate mechanisms of thrombosis and evaluate new antithrombotic regimens.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other pharmacopeial testing methods.
• Formulation R&D: Employed in the research and development of new drug delivery systems, including sustained-release formulations.

Basic Information

Product Name	Fondaparinux Sodium
CAS No.	114870-03-0
Molecular Formula	C31H43N3Na10O49S8
Molecular Weight	1728.08 g/mol
Synonyms	Fondaparinux Sodium; SR 90107A/ORG 31540; Pentasaccharide Sodium; Arixtra (Brand Name); Methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranoside, decasodium salt
EINECS	Contact for details

Quality Control

Our Fondaparinux Sodium is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest standards for pharmaceutical use. Quality is assured through comprehensive testing per relevant pharmacopeial monographs (e.g., USP, EP). A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	NLT 98.0% and NMT 102.0% (on anhydrous basis)
Water Content (KF)	NMT 5.0%
Residue on Ignition	NLT 28.0% and NMT 36.0% (as Sodium)
Related Substances (HPLC)	Individual impurity: NMT 1.0% Total impurities: NMT 3.0%
Bacterial Endotoxins	Less than 0.1 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.