Description

n-Fmoc-4-Hydroxybenzeneethanamine CAS NO 114865-17-7 is a key protected amine building block used in solid-phase peptide synthesis (SPPS) and other organic synthesis applications. This compound is essential for the controlled introduction of a phenolic hydroxyl group into peptide chains, enabling the synthesis of complex biomolecules and advanced materials. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in peptide drug discovery and the production of specialized amino acid derivatives.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial Fmoc-protected intermediate for incorporating tyrosine-like phenolic functionalities into custom peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, hormone analogs, and diagnostic agents.
• Bioconjugation Chemistry: Acts as a linker or spacer molecule for attaching peptides to surfaces, polymers, or other biomolecules via its reactive amine and hydroxyl groups.
• Combinatorial Chemistry Libraries: Employed as a building block for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Material Science: Utilized in the development of specialized polymers and functional materials that require precise amino acid-based architectures.
• Academic & Industrial Research: A fundamental reagent for organic synthesis projects focusing on amino acid derivatives and protected intermediates.

Basic Information

Product Name	n-Fmoc-4-Hydroxybenzeneethanamine
CAS No.	114865-17-7
Molecular Formula	C23H21NO4
Molecular Weight	375.42 g/mol
Synonyms	Fmoc-Tyr(2-OH)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxyphenethylamine; 2-{4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]phenyl}ethan-1-ol; Fmoc-4-Hydroxyphenethylamine; N-Fmoc-2-(4-Hydroxyphenyl)ethylamine; N-α-Fmoc-O-benzyl-L-tyrosine; Fmoc-Tyr(Bzl)-OH (common related form); 4-{2-[(Fmoc-amino)ethyl]}phenol
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Hydroxybenzeneethanamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.