Description

4-Chloro-2-(1H-Imidazol-1-Yl)Pyrimidine is a high-purity heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its dual functionality, featuring both a reactive chloro-pyrimidine group and an imidazole moiety, making it a versatile intermediate for constructing complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for creating functional polymers, ligands for catalysis, or organic electronic materials.
• Cross-Coupling Reactions: The chloro substituent makes it suitable for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, or Negishi couplings.
• Nucleophilic Substitution: The imidazole nitrogen can act as a nucleophile, allowing for further functionalization of the core structure.

Basic Information

Item	Detail
Product Name	4-Chloro-2-(1H-Imidazol-1-Yl)Pyrimidine
CAS No.	114834-04-7
Molecular Formula	C7H5ClN4
Molecular Weight	180.59 g/mol
Synonyms	4-Chloro-2-(imidazol-1-yl)pyrimidine; 2-(1H-Imidazol-1-yl)-4-chloropyrimidine; 4-Chloro-2-imidazol-1-ylpyrimidine; 1-(4-Chloropyrimidin-2-yl)-1H-imidazole; 4-Chloro-2-(1H-imidazol-1-yl)pyrimidine; 4-Chloro-2-imidazolylpyrimidine; 114834-04-7; 4-Chloro-2-(imidazol-1-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(1H-Imidazol-1-Yl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.