Description

Fmoc-α-Methyl-Dl-Tryptophan CAS NO 114779-80-5 is a protected, non-natural amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for the solid-phase peptide synthesis (SPPS) of peptides containing modified tryptophan residues, enabling the creation of complex molecular architectures with enhanced stability or altered biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating non-natural, α-methylated tryptophan analogs into peptide chains to study structure-activity relationships (SAR).
• Pharmaceutical Research: Used in the development of peptide drugs and peptidomimetics with potential applications in oncology, neurology, and metabolic disorders.
• Chemical Biology & Proteomics: Employed to synthesize labeled or modified peptides for use as probes in enzyme studies, receptor binding assays, and protein-protein interaction analysis.
• Academic Research: Serves as a specialized reagent in university and institutional labs for exploring novel synthetic methodologies and peptide chemistry.
• Fine Chemical Production: Acts as a high-value intermediate for contract manufacturing organizations (CMOs) producing custom peptides and complex organic molecules for clients.

Basic Information

Product Name	Fmoc-α-Methyl-Dl-Tryptophan
CAS No.	114779-80-5
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-α-Me-DL-Trp-OH; N-(9-Fluorenylmethoxycarbonyl)-α-methyl-DL-tryptophan; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-3-(1H-indol-3-yl)propanoic Acid; Fmoc-α-Methyltryptophan; Fmoc-DL-α-Methyltryptophan; N-Fmoc-α-methyl-DL-tryptophan; Fmoc-Amt(DL)-OH; Fmoc-α-Me-Trp-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Methyl-Dl-Tryptophan is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Optical Purity (Chiral HPLC)	DL-mixture

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.