Description

L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Alpha,5Alpha)- (9Ci) is a specialized, non-proteinogenic amino acid derivative with a defined stereochemistry, offering a unique structural scaffold for advanced chemical synthesis. This compound is valued for its role as a chiral building block and intermediate in the development of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide research, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Medicinal Chemistry Research: Used as a constrained proline analog to study structure-activity relationships (SAR) and to modulate the pharmacokinetic properties of lead compounds.
• Peptide Synthesis: Incorporated into custom peptides to introduce conformational constraints, potentially enhancing stability, bioavailability, and target specificity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to probe the function of proline-hydroxylating enzymes or other biological pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective organic synthesis to construct complex molecular architectures.

Basic Information

Product Name	L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Alpha,5Alpha)- (9Ci)
CAS No.	114717-05-4
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2S,3S,5S)-3-Hydroxy-5-methylproline; (2α,3α,5α)-3-Hydroxy-5-methyl-L-proline; 3-Hydroxy-5-methyl-L-proline; 5-Methyl-3-hydroxy-L-proline; cis-3-Hydroxy-5-methyl-L-proline; (2S,3S,5S)-5-Methyl-3-hydroxyproline; L-3-Hydroxy-5-methylproline
EINECS	Contact for details

Quality Control

We supply L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Alpha,5Alpha)- (9Ci) in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.