Description

L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Beta,5Beta)- (9Ci) is a specialized, non-proteinogenic proline derivative with a unique stereochemistry and functional group modifications. This compound matters as a high-value chiral building block and intermediate for advanced pharmaceutical synthesis and biochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly in oncology and metabolic disease research.
• Peptidomimetics & Drug Design: Used to introduce conformational constraints and enhance metabolic stability in peptide-based therapeutics and protease inhibitors.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving proline-specific enzymes like prolyl hydroxylases.
• Asymmetric Synthesis: Acts as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Natural Product Synthesis: Building block for the total synthesis of natural products containing modified proline motifs.
• Cosmetic & Personal Care Actives: Potential intermediate for synthesizing peptides used in anti-aging and skin-repair formulations.

Basic Information

Product Name	L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Beta,5Beta)- (9Ci)
CAS No.	114717-04-3
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2S,3R,5S)-3-Hydroxy-5-methylproline; (2α,3β,5β)-3-Hydroxy-5-methyl-L-proline; 3-Hydroxy-5-methylproline; 5-Methyl-3-hydroxyproline; L-3-Hydroxy-5-methylproline; cis-3-Hydroxy-5-methyl-L-proline; (2S,3R,5S)-5-Methyl-3-hydroxyproline
EINECS	Contact for details

Quality Control

Our L-Proline, 3-Hydroxy-5-Methyl-, (2Alpha,3Beta,5Beta)- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data for identity, assay, chiral purity, and impurity profiles, supporting development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.