Description

α-Gliadin (43-47) CAS NO 114691-30-4 is a defined peptide fragment derived from the α-gliadin protein, a key component of wheat gluten. This specific sequence is of significant scientific and diagnostic interest due to its role in immune recognition, particularly in conditions like celiac disease. It serves as a critical reagent for researchers and diagnostic manufacturers focused on food intolerance, autoimmune disorders, and immunology. The peptide is essential for developing assays, studying antigen-antibody interactions, and creating reference materials for gluten detection.

Application

• Celiac Disease Research: Used as a specific antigen to study T-cell activation and immune response pathways.
• Diagnostic Kit Development: A key component in the production of ELISA and other immunoassays for detecting gluten sensitivity and celiac disease antibodies.
• Antibody Production: Employed as an immunogen to generate monoclonal or polyclonal antibodies specific to α-gliadin epitopes.
• Food Safety Testing: Acts as a reference standard for calibrating equipment and validating methods used to quantify gluten in "gluten-free" labeled products.
• Pharmaceutical Research: Utilized in the development and screening of potential therapeutic agents for celiac disease, such as enzyme therapies or tolerizing vaccines.
• Biochemical Studies: Serves as a model peptide for investigating protein structure, digestibility, and the biochemical basis of gluten toxicity.

Basic Information

Product Name	α-Gliadin (43-47)
CAS No.	114691-30-4
Molecular Formula	C24H40N6O9
Molecular Weight	556.6 g/mol
Synonyms	α-Gliadin Peptide (43-47); LQLQP; H-L-Leu-Gln-Leu-Gln-Pro-OH; Gliadin Fragment 43-47; Wheat Gliadin Peptide (43-47); Gluten Peptide LQLQP; Celiac Disease-Related Gliadin Peptide; Immunogenic Gliadin Peptide
EINECS	Contact for details

Quality Control

Our α-Gliadin (43-47) is produced and controlled to meet the exacting standards required for research and in-vitro diagnostic use. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our quality system ensures traceability and consistency, supporting your critical work in immunology and diagnostics.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (MS)	Conforms
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.