Description

Preproendothelin CAS NO 114540-95-3 is a synthetic peptide fragment corresponding to the precursor sequence of endothelin, a potent vasoconstrictor. This high-purity biochemical is essential for advanced life science research, enabling the study of endothelin biosynthesis, receptor interactions, and related cardiovascular pathways. It is a critical reagent for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on hypertension, pulmonary arterial hypertension, and other vascular disorders.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies of endothelin-converting enzyme (ECE) activity and peptide processing.
• Pharmaceutical Development: Serves as a key intermediate in the investigation and screening of novel therapeutics targeting the endothelin system.
• Antibody Production: Acts as an immunogen for generating specific antibodies against preproendothelin or its cleavage products for immunoassays.
• Cell Signaling Studies: Employed in cellular models to probe the biosynthesis and secretory pathway of endothelin peptides.
• Diagnostic Assay Development: Utilized as a calibrator or control in the development of ELISA and other immunoassay kits for endothelin pathway biomarkers.
• Academic & Institutional Research: Fundamental tool for cardiovascular, renal, and endocrine research in university and government laboratories.

Basic Information

Product Name	Preproendothelin
CAS No.	114540-95-3
Molecular Formula	C128H202N36O39S5
Molecular Weight	2953.5 g/mol
Synonyms	Preproendothelin-1 (1-38), human; Big Endothelin-1 (1-38); PPET1 (1-38); Endothelin-1 Precursor (1-38); ET-1 (1-38); Prepro-ET-1; hPPET-1(1-38); Preproendothelin-1 Fragment
EINECS	Contact for details

Quality Control

Our Preproendothelin is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.