Description

(S)-Thioridazine is a high-purity enantiomer of the phenothiazine derivative, thioridazine, distinguished by its specific stereochemistry at the chiral center. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and receptor selectivity. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in neuroscience, pharmacology, and the development of chiral therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in drug manufacturing.
• Metabolite and Impurity Profiling: Essential for identifying and quantifying related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Pharmacological Research: Serves as a key chiral intermediate or tool compound in neuroscience studies, particularly for investigating dopaminergic and adrenergic receptor interactions.
• Analytical Method Development: Employed in HPLC, LC-MS, and chiral separation techniques to develop and validate assays for thioridazine and its isomers.
• Process Chemistry & Synthesis: Used as a building block or intermediate in the research-scale synthesis of novel chiral molecules and potential therapeutics.

Basic Information

Product Name	(S)-Thioridazine
CAS No.	114488-10-7
Molecular Formula	C21H26N2S2
Molecular Weight	370.57 g/mol
Synonyms	(S)-(-)-Thioridazine; (-)-Thioridazine; Levothioridazine; (S)-10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine; (S)-2-Methylmercapto-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine; Thioridazine S-(-)-enantiomer; UNII-6E0F0B61FJ
EINECS	Contact for details

Quality Control

Our (S)-Thioridazine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet stringent standards for research use. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.