Description

D-Proline, 1-Acetyl-, Methyl Ester (9Ci) is a high-purity, non-natural amino acid derivative of significant value in advanced organic synthesis. This chiral building block is essential for the development of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought by research institutions and industrial chemists working on peptide mimetics, protease inhibitors, and other bioactive compounds requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics & Drug Design: Used to construct constrained peptide analogs and scaffolds that mimic natural peptide structures with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective reactions to introduce the D-proline configuration into target molecules.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, receptor binding, and structure-activity relationships (SAR) due to its defined stereochemistry.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural products, specialty chemicals, and advanced materials.
• Agrochemical Research: Potential application in the development of chiral agrochemicals with specific biological activity.

Basic Information

Item	Detail
Product Name	D-Proline, 1-Acetyl-, Methyl Ester (9Ci)
CAS No.	114376-47-5
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	Methyl 1-acetyl-D-prolinate; (R)-1-Acetylpyrrolidine-2-carboxylic acid methyl ester; D-1-Acetylproline methyl ester; Methyl (R)-1-acetylpyrrolidine-2-carboxylate; 1-Acetyl-D-proline methyl ester; (R)-Methyl 1-acetylpyrrolidine-2-carboxylate; Proline, 1-acetyl-, methyl ester, D- (9CI)
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Acetyl-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.