Description

Neurokinin B (4-10), β-Asp(4)-Me-Phe(7)- is a synthetic peptide fragment of the neurokinin B (NKB) neuropeptide, specifically the 4-10 sequence with specific modifications. This compound is a valuable research-grade biochemical tool used to study the structure-activity relationships and signaling pathways of the neurokinin-3 (NK3) receptor. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, endocrinology, and drug discovery programs targeting tachykinin receptors.

Application

• Neuroscience Research: A key tool for investigating the physiological and pathological roles of the NKB/NK3 receptor system in the central and peripheral nervous systems.
• Drug Discovery & Development: Used as a reference standard or pharmacologic probe in high-throughput screening (HTS) assays to identify and characterize novel NK3 receptor antagonists or agonists.
• Endocrinological Studies: Applied in research exploring the regulation of gonadotropin-releasing hormone (GnRH) pulsatility and reproductive function.
• Biochemical Assay Development: Serves as a critical component in establishing and validating receptor binding assays, calcium flux assays, and other functional cellular tests for NK3 receptor activity.
• Academic & Institutional Research: Supports fundamental scientific studies in neuropeptide signaling, receptor pharmacology, and peptide chemistry.

Basic Information

Product Name	Neurokinin B (4-10), β-Asp(4)-Me-Phe(7)-
CAS No.	114317-52-1
Molecular Formula	C41H58N10O11S
Molecular Weight	899.03 g/mol
Synonyms	Neurokinin B (4-10), [β-Asp4, MePhe7]-; [β-Aspartic acid4, N-Methyl-L-phenylalanine7]-Neurokinin B (4-10); Asp-β4, MePhe7-NKB(4-10); NKB(4-10) fragment analog; Tachykinin peptide fragment; NK3 receptor ligand fragment; H-Asp-Ser-Phe-β-Asp-Gly-Leu-MePhe-NH2
EINECS	Contact for details

Quality Control

Our research-grade peptides are produced under stringent quality management systems. Each batch of Neurokinin B (4-10), β-Asp(4)-Me-Phe(7)- undergoes comprehensive analytical testing, including HPLC for purity confirmation, mass spectrometry (MS) for identity verification, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to ensure traceability and support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.