Description

3,4-Difluoro-2-Methylaniline is a high-purity fluorinated aromatic amine building block of significant commercial importance. This compound serves as a critical intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables fine-tuning of biological activity and physicochemical properties. It is primarily utilized by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antibacterial agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance metabolic stability and membrane permeability.
• Liquid Crystal & OLED Materials: Used in the production of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Acts as a monomer or curing agent in specialty polymers to impart specific thermal, chemical, or surface properties.
• Dyestuff & Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments for specialized applications.
• Research & Development: Serves as a versatile scaffold in medicinal chemistry and material science research for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,4-Difluoro-2-Methylaniline
CAS No.	114153-09-2
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	2-Methyl-3,4-difluoroaniline; 3,4-Difluoro-2-methylbenzenamine; 2-Amino-4,5-difluorotoluene; Benzenamine, 3,4-difluoro-2-methyl-; 4,5-Difluoro-2-methylaniline; 3,4-DFMA; 114153-09-2
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Methylaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline mass
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.